Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3,3,3-Trifluoropropan-1-ol
a){(R)-5,5-Difluoro-4-methyl-4-[3-(3,3,3-trifluoro-propoxy)-phenyl]-5,6-dihydro-4H-[1,3]oxazin-2-yl}-di(carbamic acid tert-butyl ester)A solution of [(R)-5,5-difluoro-4-(3-hydroxy-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-di(carbamic acid tert-butyl ester) (intermediate G3.1) (40 mg, 90.4 mumol), 3,3,3-trifluoropropan-1-ol (20.6 mg, 181 mumol), and triphenylphosphine (48.9 mg, 181 mumol) in tetrahydrofuran (1.2 ml) was treated dropwise with a solution of diethyl azodicarboxylate (40percent in toluene; 86.6 mg, 91.1 mul, 199 mumol) at room temperature over a period of 2 minutes.The mixture was stirred at room temperature for 20 hours.For the workup, the solvent was removed at reduced pressure, and the thus obtained residue was purified on a preparative silica gel TLC using a 4:1-mixture of heptane and ethyl acetate as the eluent.The {(R)-5,5-difluoro-4-methyl-4-[3-(3,3,3-trifluoro-propoxy)-phenyl]-5,6-dihydro-4H-[1,3]oxazin-2-yl}-di(carbamic acid tert-butyl ester) (8.3 mg, 17percent yield) was obtained as a light yellow oil. MS (ISP): m/z=539.4 [M+H]+.
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Reference:
Patent; Hilpert, Hans; Narquizian, Robert; Pinard, Emmanuel; Polara, Alessandra; Rogers-Evans, Mark; Woltering, Thomas; Wostl, Wolfgang; US2012/295900; (2012); A1;,
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