As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1-Chloro-2-methyl-2-propanol
To a stirred solution of ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (2.5 ml, 2.4 mmol) in N,N-dimethylacetamide (3.0 ml, 32 mmol) was added potassium carbonate (766 mg, 65 percent purity, 3.60 mmol) and 1-chloro-2-methylpropan-2-ol (490 mI, 4.8 mmol) and the mixture was stirred at 80° C for 10 h. Water was added, and the mixture was extracted with ethyl acetate. The organic phase was washed with a saturated sodium chloride solution, dried (sodium sulfate), filtered and the solvent was removed in vacuum. Silicagel chromatography gave 470 mg (69 percent yield) of the title compound and 33.0 mg (5 percent yield) of a second isomer, Intermediate 34. LC-MS (Method 1 ): Rt = 1 .04 min; MS (ESIpos): m/z = 281 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) d [ppm]: 1 .07 (s, 6 H), 1 .27 (t, 3 H), 4.14 (s, 2 H), 4.19 – 4.30 (m, 2 H), 4.85 (s, 1H), 8.37 (d, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 558-42-9.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; CHRIST, Clara; BRIEM, Hans; FARIA ALVARES DE LEMOS, Adelaide, Clara; BADER, Benjamin; HOLTON, Simon; BOeMER, Ulf; LIENAU, Philip; KUHNKE, Lara, Patricia; (122 pag.)WO2019/185525; (2019); A1;,
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