Adding a certain compound to certain chemical reactions, such as: 34626-51-2, 5-Bromopentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Bromopentan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 5-Bromopentan-1-ol
To a solution of 5-bromopentan-1-ol (0.43 mL, 3.00 mmol) in tetrahydrofuran (15 mL) at 0 C under an atmosphere of nitrogen was added imidazole (210 mg, 3.00 mmol) and t-butylchlorodiphenylsilane (0.78 mL, 3.00 mmol) at 0 C. After 5 h at room temperature, the reaction mixture was quenched by addition of water (5 mL) and the mixture was extracted with diethyl ether. The organic layer was washed with brine, dried over magnesium sulfate, filtered and evaporated in vacuo. The resulting crude residue was purified on a Biotage purification apparatus (silica gel, 0-10% ethyl acetate in hexanes gradient) to yield the title compound (17, 980 mg, 2.42 mmol, 81%) as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 7.72-7.69 (m, 4H), 7.48-7.39 (m, 6H), 3.70 (t, J = 6.4 Hz, 1H), 3.42 (t, J = 6.8 Hz, 1H), 1.91-1.84 (m, 2H), 1.62-1.58 (m, 2H), 1.47-1.42 (m, 4H), 1.09 (s, 9H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,34626-51-2, 5-Bromopentan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Kim, Min Ju; Lee, Suk Ho; Park, So Ok; Kang, Hyunku; Lee, Jun Sung; Lee, Ki Nam; Jung, Myung Eun; Kim, Jeongmin; Lee, Jinhwa; Bioorganic and Medicinal Chemistry; vol. 19; 18; (2011); p. 5468 – 5479;,
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