Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks
To a mixture, kept under stirring, of C6F13CH2CH2OH(252 g, 0.692 moles), tetrahydrofurane (350 ml) and cyclohexane (300 ml) at 250C, an aqueous solution ofNaOH (400 ml, 50%) was added drop-wise. After stirring for 2 hours, benzyltriethyl ammonium chloride (25 g, 0.11 moles) as phase transfer catalyst, and then 1- bromopentane (209 g, 1.38 moles) were added. The reaction mixture was kept under stirring at 400C for 40 hours, then at 700C for 8 hours. The resulting mixture was poured into water and the organic phase thus ob- tained was washed two times with water. After removing the fraction having a low boiling point, the raw product was subjected to distillation at reduced pressure, thus obtaining 215 g of C6F13CH2CH2O (CH2) 4CH3 (yield 72%, boiling point 110C/6 mbar, n 1.3385) . Spectrographic data confirm the obtained structure: GC/MS m/z at 435 (M+H)+, 377 (M-CH2CH2CH2CH3) +, 71 (- CH2CH2CH2CH2CH3) + ; for NMR data see Tables 1-2.
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Reference:
Patent; ALChiMI.A. S.r.l.; WO2009/133575; (2009); A1;,
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