Adding a certain compound to certain chemical reactions, such as: 100058-61-5, 3-(Benzyloxy)cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 100058-61-5, blongs to alcohols-buliding-blocks compound. Product Details of 100058-61-5
Preparation of 3-(benzyloxy)cyclobutyl sulfochloridate (CC): A solution of compound BB (1.7 g, 9.53 mmol) in DCM (100 ml) was treated with triethylamine (3.34 ml, 23.84 mmol) followed by MeSO2Cl (MsCl) (1.47 ml, 19.07 mmol) and stirred at 25 C. for 30 minutes. The reaction mixture was poured into water and extracted with DCM. The organic layer was dried over Na2SO4, filtered, and concentrated to provide crude CC. Yield: 3.5 g. 1H NMR (400 MHz, CDCl3): 7.36-7.27 (m, 5H), 4.67-4.60 (m, 1H), 4.42 (s, 2H), 3.76-3.69 (m, 1H), 2.97 (s, 3H), 2.85-2.78 (m, 2H), 2.35-2.28 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100058-61-5, 3-(Benzyloxy)cyclobutanol, and friends who are interested can also refer to it.
Reference:
Patent; Pfizer Inc; US2008/280879; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts