Application of

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23147-58-2, name is Glycerol aldehyde dimer. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 23147-58-2

Example B39; 2-((2R,3aR,12bS)-2-[(dimethylamino)methyl]-11-fluoro-3,3a,8,12b-tetrahydro- dibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrol-l(2H)-yl)ethanol (final compound 39); Hydroxyacetaldehyde dimer (2,5-dihydroxy-l,4-dioxane) (240 mg, 2.0 mmol) was dissolved in MeOH (25 mL) and stirred at 40C for 30 minutes, then amine compound 37 (124 mg, 0.40 mmol) was added and stirring at 40 C continued for another 30 minutes. After cooling down to room temperature, AcOH (120 mg, 2.0 mmol) was EPO added, followed by sodium cyanoborohydride (188 mg, 3.0 mmol) and the resulting mixture was stirred for 2 hours. After this time it was quenched with concentrated HCl (2 mL), treated with solid NaHCO3 (2.94 g, 35 mmol), IN sodium hydroxide (3 mL). About 20 mL of MeOH was removed in vacuo, the residue diluted with water (30 mL), and extracted with EtOAc (3 x 30 mL). The combined organics were washed with water (5 x 25 mL), brine (30 mL), dried (K2CO3), evaporated in vacuo and purified by column chromatography (Kieselgel 60, 230-400 mesh, CH2Cl2-MeOH 95/5 to 90/10 to 85/15) to give amine compound 39 (80 mg, 0.244 mmol, 61 %) as colorless oil.HRMS Calcdfor C22H27FN2O: 354.2107; Found: 354.2107.

With the rapid development of chemical substances, we look forward to future research findings about 23147-58-2.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/61392; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts