Adding a certain compound to certain chemical reactions, such as: 372-30-5, Ethyl 4,4,4-trifluoro-3-hydroxybutyrate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H9F3O3, blongs to alcohols-buliding-blocks compound. COA of Formula: C6H9F3O3
(1) Protection of a hydroxyl group of ethyl 4,4,4-trifruolo-3-hydroxybutyrate with dihydropyran With stirring, 7 ml of conc. hydrochloric acid was added dropwise to a mixture of 33.4 g of R-(+)-ethyl 4,4,4-trifluoro-3-hydroxybutyrate and 22.6 g of dihydropyran under ice cooling. After the dropwise addition, stirring continued at room temperature for another 5 hours. The reaction mixture was poured into ice water, neutralized with sodium hydrogen carbonate, and then extracted with methylene chloride. After drying, the solvent was evaporated. The residue was distilled under reduced pressure of 6 mmHg to obtain 41.3 g of final ethyl 4,4,4-trifluoro-3-tetrahydropyranyloxybutyrate (1) (yield 85 %).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,372-30-5, Ethyl 4,4,4-trifluoro-3-hydroxybutyrate, and friends who are interested can also refer to it.
Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; US5264150; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts