Reference of 46190-45-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate. A new synthetic method of this compound is introduced below.
Step 3 4-(2-Phenoxy-ethyl)-benzoic Acid Methyl Ester 72 4-(2-Hydroxyethyl)benzoic acid methyl ester 71 (1.622 g, 9.00 mmol), triphenyl phosphine (3.541 g, 13.50 mmol), and diethyl azodicarboxylate (2.13 ml, 13.50 mmol) were dissolved in 50 ml of tetrahydrofuran at room temperature and allowed to stir for 30 minutes. Phenol (0.847 g, 9.00 mmol) was added and the mixture was allowed to stir overnight. The mixture was diluted with water and extracted with diethyl ether. The extracts were dried over anhydrous sodium sulfate and concentrated en vacuo. The residue was purified by flash chromatography on silica eluted with 99:1 hexane/acetone to give 387 mg (16.8%) of 4-(2-phenoxy-ethyl)-benzoic acid methyl ester 72 as a clear oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,46190-45-8, Methyl 4-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.
Reference:
Patent; Cournoyer, Richard Leo; Keitz, Paul Francis; Lowrie Jr., Lee Edwin; Muehldorf, Alexander Victor; O’Yang, Counde; Yasuda, Dennis Mitsugu; US2001/56100; (2001); A1;,
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