With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.
The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13330-96-6, name is 4-(Dimethylamino)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H15NO
Example 974-(Dimethylamino)butyl 2-(3-((2-ammo-4-(butylammo)-6-methylpyrimidin-5- yl)methyl)-4-methoxyphenyl)acetate, saccharin salt HATU (382 mg) was added to a stirred solution of the product from example 83 step (iv)(300 mg), 4-(dimethylamino)-l-butanol (196mg) and triethylamine (0.233ml) in DMF(3mL). The mixture was stirred at rt for Ih and then diluted with MeCN (2mL) and purified via RPHPLC. The purified product was dissolved in MeCN (ImL) and saccharin(14.84mg) was added and the solution was stirred for lOmin. The solvent was evaporated under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white solid, 31 mg.1H NMR DMSOdO: delta 7.66 – 7.55 (m, 7H), 7.10 (dd, IH), 6.96 (d, IH), 6.72 (d IH), 4.00 (t, 2H), 3.83 (s, 3H), 3.68 (s, 2H), 3.53 (s, 2H), 3.42 – 3.33 (m, 2H), 3.02 – 2.93 (m, 2H),2.71 (s, 6H), 2.10 (s, 3H), 1.68 – 1.51 (m, 4H), 1.47 (q, 2H), 1.27 – 1.15 (m, 2H), 0.85 (t,3H)LC-MS m/z 458 multimode +
With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.
Reference:
Patent; ASTRAZENECA AB; DAINIPPON SUMITOMO PHARMA CO., LTD; WO2009/67081; (2009); A1;,
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