Reference of 623-04-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 623-04-1 as follows.
To a solution of 4-aminobenzylalcohol (300 mg, 2.44 mmol) in 5 mL of 10% HCl aqueous solution wasadded NaNO2 (201 mg, 2.92 mmol) in 3 mL aqueous solution at 0 C andstirred for 30 min. Then NaN3 (190 mg, 2.92 mmol) in 3 mL aqueoussolution was added at 0 C and stirred for another hour. The reaction mixturewas warmed to 25 C, diluted with ethyl acetate, washed with water and brine,dried over Na2SO4, concentrated in vacuo and subjected tosilica gel chromatography. A yellow oil 3(315 mg, 86% yield) was obtained by silica gel column chromatography using Petroleum ether/EtOAc (5:1, v:v) as eluent. 1HNMR (500 MHz, CDCl3)delta 7.23 (d, J= 8 Hz, 2H), 6.93 (d, J = 8.5 Hz,2H), 4.51 (s, 2H), 2.04 (s, br, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.
Reference:
Article; Chen, Tao; Zheng, Yi; Xu, Zhaochao; Zhao, Miao; Xu, Yongnan; Cui, Jingnan; Tetrahedron Letters; vol. 54; 23; (2013); p. 2980 – 2982;,
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