With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, molecular weight is 230.1401, as common compound, the synthetic route is as follows.Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin
The synthetic steps of 4-trifluoromethyl-7-propylenecarbonyloxycoumarin are as follows:(1) To 10 mL of a solution containing 0.5 mmol of 4-trifluoromethyl-7-hydroxycoumarin and 0.625 mmol of triethylamine in a tetrahydrofuran solution, slowly add 0.6 mmol of acryloyl chloride chloride to the reaction flask within 30 min. Dissolved in 5 mL of tetrahydrofuran), the temperature is controlled at 0 ° C;(2) After stirring for 1 hour under ice bath conditions, the temperature of the solution was raised to room temperature and stirred overnight. ;(3) The reaction solution was subjected to a solvent under reduced pressure, and the residue was purified by silica gel chromatography eluting with ethyl acetate-hexane (1:3 v/v)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, and friends who are interested can also refer to it.
Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (12 pag.)CN103755672; (2016); B;,
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