Extracurricular laboratory: Synthetic route of 2-Methyl-2-(methylamino)propan-1-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27646-80-6, its application will become more common.

Synthetic Route of 27646-80-6 ,Some common heterocyclic compound, 27646-80-6, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(4-Amino-3,5-dichlorophenyl)-4,5,5-trimethylmorpholin-2-ol (5)Lambda/-Methyl-2-amino-2-methyl-propan-1-ol (4) (4.6 g, 44.6 mmol) was added to a mixture of compound 2 (4.2 g, 14.8 mmol) in chloroform (17 ml). The mixture was stirred at room temperature for 2 h, and then water (9 ml) was added. The mixture was stirred for 1 h, and then the solid was filtered. The solid was triturated with water (1 L) to give the desired compound (1.2 g, 91 percent). 1H NMR (400 MHz, DMSO): 0.94 (6H, s), 3.18 (2H, d J=4.4 Hz), 3,93 (2H, s), 4.55 (1 H, m), 6.40 (2H, s), 7.84 (2H, s); 13C NMR (100 MHz1 DMSO): 24.21 , 48.87, 53.73, 68.52, 117.92, 124.57, 125.79, 128.62, 146.07, 195.30; LC-MS: 291 , 292, 293 (M + H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27646-80-6, its application will become more common.

Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts