Synthetic Route of 37585-16-3, Adding some certain compound to certain chemical reactions, such as: 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37585-16-3.
General procedure: A 100-mL, three-necked flask equipped with a condenser was charged with Ph3P (2.20 g, 8.4 mmol), Et3N (0.85 g, 8.4 mmol),CBr4 (2.79 g, 8.4 mmol), and fluorine-containing carboxylic acid(2.8 mmol) in toluene (25.0 mL) at 0 C under a nitrogen atmosphereand the solution was then stirred for 10 min. 2-Aminobenzyl alcohol 1 (2.8 mmol) was added to the reaction mixture. Once theaddition was complete, the reaction mixture was heated to reflux for1-3 h. After cooling, the solvent was removed by rotary evaporator,the residue was then carefully washed three times with hexane-EtOAc (4:1), and the precipitate was removed by filtration. The filtratewas combined and concentrated by rotary evaporator. The residue was then purified by column chromatography (hexane-EtOAc,4:1) to give the product.
According to the analysis of related databases, 37585-16-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Zeng-Xue; Zhang, Tai-Feng; Ma, Qing-Wen; Ni, Wei-Gui; Synthesis; vol. 46; 24; (2014); p. 3309 – 3314;,
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