Reference of 115-20-8 ,Some common heterocyclic compound, 115-20-8, molecular formula is C2H3Cl3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 38 mg (0.25 mmol) of the required alcohol is added at room temperature to a mixture of 134 mg (0.25 mmol) of acid in 30 ml of DCM, 30.8 mg (0.25 mmol) of DMAP and 49 mg (0.25 mmol) of EDCI. The mixture is stirred for 20 hours at room temperature and is then evaporated todryness. A pasty oil is obtained, which is purified by chromatography (SiO2,2/3 EtOAc/heptane) to give 127 mg (76%) of a pasty product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; WO2006/10423; (2006); A2;,
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Alcohols – Chemistry LibreTexts