The origin of a common compound about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106-28-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 106-28-5, blongs to alcohols-buliding-blocks compound. Computed Properties of C15H26O

Farnesol (10) (2.0 mL, 8 mmol) was dissolved in anhydrous DMF (80 mL) and cooled to 0 C. Collidine (6.3 mL, 48 mmol) and MsCl (1.3 mL, 16 mmol) were added to the mixture. After stirring at 0 C for 15 min, anhydrous LiCl (1.35 g, 32 mmol) was added. The reaction was stirred at 0 C for 3 h. H2O (80 mL) was added and the mixture was extracted with hexane (50 mL 3). The combined organic phases were washed with CuSO4 (sat.), NaHCO3 (sat.) and brine. The resulting solution was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Compound 11 was obtained as a yellow oil and used in the next step without purification.1H NMR (300 MHz, CDCl3): d (ppm) 5.46 (1H, t, J = 8.0), 5.12-5.08 (2H, m), 4.12 (2H, d, J = 8.0), 2.23-1.98 (8H, m), 1.73 (3H, s),1.66 (3H, s), 1.61 (6H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106-28-5, its application will become more common.

Reference:
Article; Tang, Xiaoping; Demiray, Melodi; Wirth, Thomas; Allemann, Rudolf K.; Bioorganic and Medicinal Chemistry; vol. 26; 7; (2018); p. 1314 – 1319;,
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