Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4461-39-6, name is N-(2-Hydroxyethyl)-1,3-propanediamine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H14N2O
Lactone 14 (84 mg, 0.26 mmol) was dissolved in CHCl3 (15 mL) with stirring and a solution of 3-(2-hydroxyethyl)propylamine (20, 35 mg, 0.30 mmol) in CHCl3 (1 mL) was added. The mixture was heated at reflux with stirring under an argon atmosphere for 22 h and concentrated in vacuo until ?1 mL of solvent remained. Hexanes (1 mL) were added and the suspension was filtered and dried under high vacuum to provide 30 (93 mg, 84%) as a purple solid: mp 198 C. 1H NMR (500 MHz, DMSO-d6) delta 8.38 (d, J = 8.7 Hz, 1H), 8.02 (d, J = 2.4 Hz, 1H), 7.76 (dd, J = 8.7, 2.4 Hz, 1H), 7.63 (s, 1H), 7.10 (s, 1H), 6.18 (s, 2H), 4.59-4.27 (m, 3H), 3.44 (t, J = 5.7 Hz, 2H), 2.67 (t, J = 6.4 Hz, 2H), 2.58 (t, J = 5.8 Hz, 2H), 1.92-1.71 (m, 2H); ESIMS m/z (rel intensity) 427/429 (MH+, 100/31); HRESIMS calcd for C22H20ClN2O5 427.1061 (MH+), found 427.1067; HPLC purity, 98.60% (0.1% TFA in MeOH, 100%).
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Reference:
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
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