As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 558-42-9
Step 1: Methyl 1H-pyrazole-3-carboxylate (2.52 g, 20 mmol, 1 equiv.) was dissolved in DMF (20 mL). K2CO3 (5.53 g, 40 mmol, 2 equiv.) was added, followed by 1-chloro-2-methyl- 2-propanol (2.67 mL, 26 mmol, 1.3 equiv.). The reaction mixture was heated to 80 °C for 40 hours and cooled to room temperature. The reaction mixture was poured into water, extracted with EtOAc, and the combined organic extracts were washed with water and brine. The organic layer was concentrated, and the crude residue was purified on SiO2 (25 100percent EtOAc/Hexanes) to afford the title compound as a colorless oil that solidified upon standing (2.08 g, 53percent yield).
With the rapid development of chemical substances, we look forward to future research findings about 558-42-9.
Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan Reddy; MILES, Dillon Harding; POWERS, Jay Patrick; ROSEN, Brandon Reid; SHARIF, Ehesan Ul; (109 pag.)WO2018/213377; (2018); A1;,
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