Some scientific research about 3,3,3-Trifluoropropan-1-ol

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 2240-88-2, blongs to alcohols-buliding-blocks compound. Product Details of 2240-88-2

Step 5; Preparation of 2-cvclopropyl-9-methyl-4-(3.3,3-trifluoropropoxy)-6,7,8,9- tetrahvdro-5H-pyrimido[4,5-d]azepine dihvdrochloride; [073] To a solution of 3,3,3-trifluoropropan-1-ol (14 mg, 0.12 mmol) in 1 ,4-dioxane (1 ml.) was added potassium tert-butoxide (58 mg, 0.52 mmol), and the resulting mixture was stirred at rt for 15 min. tert-Butyl 4-chloro-2-cyclopropyl-9-methyl-5,6,8,9-tetrahydro- 7H-pyrimido[4,5-d]azepine-7-carboxylate (35 mg, 0.10 mmol) was then added, and the mixture was heated at 80°C overnight. The reaction was cooled to rt and filtered through a pad of Celite.(R).. The filtrate was concentrated under reduced pressure, and the crude material was re-dissolved in 1 ,4-dioxane. A 4M solution of hydrochloric acid in dioxane (0.1 ml_, 0.4 mmol) was added, and the mixture was stirred for 3 h. The dioxane solvent was removed under reduced pressure, and the crude residue was triturated with ethyl acetate to afford 12 mg (29percent) of desired product.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/44762; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts