Reference of 505-10-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 505-10-2, name is 3-(Methylthio)propan-1-ol, molecular formula is C4H10OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1 : Synthesis of 3-(methylsulfonyl)propan-l-ol 12-a3-(methylthio)propan-l-ol (200 g, 1900 mmol, CAS 505-10-2) was dissolved in CH2C12 (2000 mL). The mixture was cooled to 0C. Then w-CPBA 85% in water (970 g, 5700 mmol, CAS 937-14-4) was added portion wise keeping the temperature between 0 and 5C. After addition, the mixture was allowed to warm to 25C and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether: ethyl acetate = 3 : 1 and then ethyl acetate: methanol = 10: 1) to yield the intermediate 12-a (75 g, 29%).
According to the analysis of related databases, 505-10-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN R&D IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; WO2012/80450; (2012); A1;,
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