Electric Literature of 6351-10-6 , The common heterocyclic compound, 6351-10-6, name is 2,3-Dihydro-1H-inden-1-ol, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
DMAP (143.8 mg, 1.25 mol) and acetic anhydride (1185.6 L,12.48 mmol) were added to a rac-indanol (rac-2), 500 mg,4.16 mmol) solution in dichloromethane (40 mL). The reaction wasstirred at room temperature during 4 h and after that time, thesolvent was evaporated under reduced pressure. The resultingcrude was purified by flash chromatography on silica gel (5-95%EtOAc/hexane) to afford the desired rac-indanyl acetate (rac-3) asa yellow liquid in 80% yield.
The synthetic route of 6351-10-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; De Mattos, Marcos Carlos; De Fonseca, Thiago Sousa; Da Silva, Marcos Reinaldo; De Oliveira, Maria Da Conceicao Ferreira; De Lemos, Telma Leda Gomes; De Marques, Ricardo Araujo; Applied Catalysis A: General; vol. 492; 1; (2015); p. 76 – 82;,
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