456-47-3 , The common heterocyclic compound, 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A solution of acetonitril (10 mL, 1mmol) and periodic acid was placed in flask and stir for the 15 min. Then, a mixture of alcohols (1mmol) and S-COCC (1%mmol) was added and the resulting mixture was stirred at room temperature for a suitable period (Table 3) and completion of the reaction investigated byTLC (n-hexane/EtOAc; 2:1) analysis. Then, EtOAc (20ml) was subjoined to the reaction mixture and after being washed with water/sodium solfite (1:1), the mixture was filtered off. The solvent was vaporized and produced pure products.
According to the analysis of related databases, 456-47-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Shiri, Lotfi; Sheikh, Davood; Sheikhi, Masoome; Revue Roumaine de Chimie; vol. 59; 10; (2014); p. 825 – 834;,
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