517-21-5, Adding a certain compound to certain chemical reactions, such as: 517-21-5, Sodium 1,2-dihydroxyethane-1,2-disulfonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 517-21-5, blongs to alcohols-buliding-blocks compound.
6-Methylquinoxaline; A solution of 3,4-diaminotoluene (Aldrich, 100 g, 0.82 mol) in 600 mL of hot water (temp. 70-75 C.) was added rapidly to a 60 C. slurry of glyoxal-sodium bisulfite adduct (Aldrich, 239.5 g, 0.9 mol, 1.1 eq) in 400 mL of water. The resulting dark-brown clear solution was heated at 60 C. for 1 hr, then 5 g (0.02 mol) of additional glyoxal adduct was added. The mixture was allowed to cool to r.t. and filtered through a paper filter. The filtrate was neutralized with 5 M aq. NaOH to pH 7.5-7.8 and then extracted with ether (4¡Á400 mL). The extract was dried over Na2SO4 and concentrated on a rotary evaporator to afford 92 g of brown oil which was distilled in vacuum (bp. 100-102 C. at 10 mm Hg; Cavagnol, J. C.; Wiselogle, F. Y. J. Am. Chem. Soc. 1947, 69, 795; 86 C. at 1 mm Hg). Yield 89 g (75%) as a pale-yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,517-21-5, its application will become more common.
Reference:
Patent; Wyeth; US2005/282820; (2005); A1;,
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