Analyzing the synthesis route of Trichloroethanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115-20-8, Trichloroethanol, other downstream synthetic routes, hurry up and to see.

Reference of 115-20-8, Adding some certain compound to certain chemical reactions, such as: 115-20-8, name is Trichloroethanol,molecular formula is C2H3Cl3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115-20-8.

Example 1 Preparation of intermediate 2, 2, 2-trichloroethyl 4-bromobutyrate A stirred solution of 4-bromobutyric acid (3.34 g, 20.0 mmol) in toluene (50 ml) was added 2,2, 2-trichloroethanol (14.94 g, 0.10 mol) and p-toluenesulfonic acid monohydrate (7.60 g, 40.0 mmol) and refluxed with a Dean-Stark trap attached for 6 h. Water was removed continuously. The reaction mixture was cooled to room temperature and concentrated in vacuo. The mixture was added CH2CI2 (75 ml) and washed with H2O (3 x 25 ml). The organic layer was dried over Na2SO4, filtered and evaporated in vacuo to leave an oil. The residue was distilled to leave the title compound as a colourless oil (4.77 g, 79.9 %) (bp 100 C at 0.5 mmHg). tH-NMR (300 MHz, CDCl3) : 5 4.74 (s, 2H), 3.48 (t, 2 H), 2.65 (t, 2 H), 2.21-2. 13 (m, 2 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115-20-8, Trichloroethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIO-MEDISINSK INNOVASJON AS; WO2005/61483; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts