Application of 15852-73-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15852-73-0, name is (3-Bromophenyl)methanol. A new synthetic method of this compound is introduced below.
Preparation of [ (3-BROMOBENZYL) OXYL (TERT- butyl) dimethylsilane 232 mg (1.24 mmol) of 3-bromo-benzylalcohol was dissolved in 50 ml of methylene chloride, and 126 mg (1.85 mmol) of imidazole and 224 mg (1.49 mmol) of tert-butyldimethylsilyl chloride were added thereto, followed by stirring at room temperature. After 2 hours, a resulting white solid was filtered off, and the remaining organic layer was washed with 20 ml of 1 N aqueous hydrochloric acid and 20 ml of saturated aqueous NaCl, then dried over anhydrous MGS04. Removal of solvent in vacuo provided 306 mg (1.02 mmol) of the title compound at 82.3% yield. 1H NMR (CDCL3, PPM) ; 6 7.37 (1H, s), 7.26 (1H, d), 7.13 (1H, d), 7.08 (1H, q) FAB MS (m/e) = 302 [M+1]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15852-73-0, (3-Bromophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; LG LIFE SCIENCES LTD.; WO2004/80979; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts