Reference of 27489-62-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.1735, as common compound, the synthetic route is as follows.
A solution of trans-4-aminocyclohexanol (5 g,33 mmol) in 1,4-dioxane (100 mL) was cooled to 0 C. After 15 min, sodium hydroxide (1.6 g,40 mmol) dissolved in water (40 mL) was added and allowed to cool for an additional 15 min. Asolution of di-tert-butyl dicarbonate (7.9 g, 36 mmol) dissolved in 1,4-dioxane (65 mL) was thenadded to the solution of aminoalcohol and allowed to stir at rt for 14 h. The reaction wasquenched by the addition of 1 M HCl (100 mL) followed by EtOAc (150 mL). The layers wereseparated and the aqueous layer was extracted further with EtOAc (2 × 150 mL). The combinedorganic layers were washed sequentially with water (100 mL), brine (100 mL), and dried(Na2SO4) before being concentrated in vacuo to give a white solid (5.3 g, 75%). Note: Theproduct can be carried forward to the mesylation step without further purification
The chemical industry reduces the impact on the environment during synthesis 27489-62-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Harty, Matthew; Nagar, Mitesh; Atkinson, Logan; Legay, Christina M.; Derksen, Darren J.; Bearne, Stephen L.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 390 – 393;,
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