Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3344-77-2, name is 12-Bromododecan-1-ol. A new synthetic method of this compound is introduced below., Safety of 12-Bromododecan-1-ol
Tetrahydro-2-(12-bromododecanoxy)-2H pyran To a solution of 12-bromo-1-dodecanol (1 mole) in dichloromethane containing pyridinium p-toluenesulfonate (P-TSA) is added dihydropyran (2 moles). The reaction mixture is stirred for 24 hours and then washed twice with water and dried over anhydrous MgSO4. The dichloromethane is removed under reduced pressure. If necessary the resulting product is purified by chromatography on silica gel. Coupling of polyethylene glycol to the terahydropyran derivative The tetrahydropyran derivative described above, dissolved in dry benzene, is added to a solution of polyethylene glycol (1 mole) in dry benzene containing NaH (1 mole).
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Reference:
Patent; Protein Delivery, Inc.; US6191105; (2001); B1;; ; Patent; Protein Delivery, Inc.; US5681811; (1997); A;,
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