New downstream synthetic route of 722-92-9

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 12a-e in DMSO (500 L) were added 4-(hexafluoro-2-hydroxyisopropyl)aniline (2 eq.)and N,N-diisopropylethylamine (2 eq.) at room temperature. The mixture was stirred for 15 min at 100 C,then poured into dilute hydrochloric acid and extracted with EtOAc. The organic layer washed with brine,dried over sodium sulfate and concentrated. The residue was purified by recrystallization from MeOH.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kaitoh, Kazuma; Toyama, Hirozumi; Hashimoto, Yuichi; Fujii, Shinya; Heterocycles; vol. 95; 1; (2017); p. 547 – 556;,
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