Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59101-28-9, name is 16-Bromohexadecan-1-ol. A new synthetic method of this compound is introduced below., SDS of cas: 59101-28-9
To a solution of 16-bromohexadecarboxylic acid (10.00 g, 30.0 mmol) in 80 ml THF was added BH3 (70 ml, 70mmol, 1 M in THF) slowly at 0 C. After addition, the reaction mixture was stirred at room temperature for 60-90 minute.The mixture was cooled to 0 C and 80 mL water was added. The aqueous layer was extracted with hexanes (2x100mL). The combined organic layer was washed by 100 mL water, dried with sodium sulfate and concentrated to give awhite solid. The solid was dissolved into). To a solution of this while solid in 100 mL DMF was added potassium thioacetateat room temperature. After stirring at room temperature for 60 -90 minutes, 150 mL ethyl acetate was added to thereaction mixture, followed by 450 mL hexanes and 50 mL water. After being washed by three portions of water, theorganic layer was dried over sodium sulfate and concentrated.. After column chromatography on silica gel (silica gel:(200 g; eluting solvents: 5% ethyl acetate in hexanes; 15% ethyl acetate in hexanes; 25% ethyl acetate in hexanes),K133 was obtained as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 4.31 (t, J=5.1Hz, 1 H, OH),3.37 (t, J=5.1Hz, 2H,CH2OH), 2.81 (t, J=6.9Hz, 2H, SCH2), 2.31 (s, 3H, CH3COS), 1.50 (m, 2H, CH2CH2OH), 1.40 (m, 2H, CH2CH2S), 1.23(br s, 24H, CH2).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 59101-28-9, 16-Bromohexadecan-1-ol.
Reference:
Patent; Clinical Micro Sensors, Inc.; CHUNLIN, Tao; EP2220102; (2014); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts