Application of 495-76-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 495-76-1 as follows.
5-(Bromomethyl)-1,3-benzodioxole was prepared using reportedmethod [30]. Take a 250 ml round bottom flask A charged with 1,3-benzodioxole-5-methanol (5 g; 32.86 mmol) in dry diethyl ether(50 ml). Take another 100 ml round bottom flask B loaded with 3.1 ml(32.86 mmol; 1 equiv.) of phosphorous tribromide dissolved in 40 mlof diethyl ether. A dropwise addition was carried out from flask B toflask A maintaining the temperature at 0 C for and stirred for 15 min.After the completion of the reaction, the reaction mixture was workedupwithwater (3× 100ml) using a separating funnel followed bywashingwith brine (1:1). After drying over sodium sulphate and filtration,the solvent was evaporated on a vacuum rotary evaporator. The crudewas recrystallized in petroleum ether to get the desired white solidproduct.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,495-76-1, its application will become more common.
Reference:
Article; Sehrawat, Hitesh; Kumar, Neeraj; Tomar, Ravi; Kumar, Loveneesh; Tomar, Vartika; Madan, Jitender; Dass, Sujata K.; Chandra, Ramesh; Journal of Molecular Liquids; vol. 302; (2020);,
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