With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.name: Diethylene Glycol Monoethyl Ether
Example Al 4; a. Preparation of intermediate 38; NaH (60 % in oil; 0.0072 mol) was added portionwise at 0 C to a solution of 2-(2- ethoxyethoxy)-ethanol (0.0072 mol) in THF (12.5 ml) under N2 flow. The mixture was stirred at 0C for 1 hour. A solution of intermediate 10 (0.006 mol) in THF (12.5 ml) was added dropwise. The mixture was stirred and refluxed for 18 hours and was then cooled to room temperature. EtOAc and H2O were added. The organic layer was washed with H2O and then with saturated NaCl. The separated organic layer was dried (MgSO4), filtered and the solvent was evaporated. Yield: 2.5 g intermediate 38 (97 %). EPO
At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/436; (2007); A1;,
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