A new synthetic route of 7-Bromo-1-heptanol

The synthetic route of 10160-24-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 7-Bromo-1-heptanol

To a stirred solution of (S)-3- (1-CARBAMOYL-1,1-DIPHENYLMETHYL)pyrrolidine (40 g, 142.7 mmol) and triethylamine (59.6 mL, 428 mmol) in acetonitrile (1. 1 L) at 40C under a nitrogen atmosphere was added 7-bromo-1-heptanol (24 mL, 146 mmol) in acetonitrile (100 mL) dropwise. The reaction mixture was heated to 50C for 9 hours. The reaction mixture was allowed to cool before removing the solvent under reduced pressure. The crude residue was dissolved in dichloromethane (500 mL) and the organic layer washed with saturated aqueous sodium bicarbonate (2 x 300 mL), followed by water (300 mL) and saturated aqueous sodium chloride (300 mL), and then dried over magnesium sulfate (10 g). The magnesium sulfate was filtered off and washed with dichloromethane (100 mL). The solvent was then removed in vacuo to give the crude product which was purified on a short column (SIO2) by varying the eluant from 19: 1: 0.1 to 3: 1: 0.1 CH2CL2/MEOH/NH40H to give 31.35 g of the title intermediate as a white solid (56% yield ; >95% purity by HPLC Method A).

The synthetic route of 10160-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE, INC.; WO2004/41806; (2004); A2;,
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