Extracurricular laboratory: Synthetic route of 1,3-Diaminopropan-2-ol

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,3-Diaminopropan-2-ol

A solution of 1,3-diamino-2-propanol (3.15 g,0.035 mol) and Et3N (4.85 mE, 0.035 mol) in methanol (120mE) was heated to 45 C. To the solution, (l3oc)20 (17.05 g,0.078 mol) in methanol (80 mE) was dropwise added slowly.The reaction solution was stirred at 45 C. for 30 mm. Afteradditional stirring at room temperature for 1.5 h, the solventwas removed under reduced pressure. The crude productwas extracted with diethyl ether (200 mEx3) and dried oversodium sulfate to yield the compound 2 (9.94 g, 97.8%) asa white powdet EC-MS mlz (ES), 291.19 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; RC Biotechnologies, Inc.; HUANG, Chang Jiang; FANG, Jianmin; YE, Hui; ZHANG, Lezhi; (63 pag.)US2018/55948; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts