With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol
To a solution of 3,3,3-trifluoropropan-1-ol (5.0 g, 43.8 mmol) in CH2Cl2 (25 mL) and pyridine (25 mL) was added 4-(dimethylamino)pyridine (0.27 g, 2.2 mmol) followed by p-toluenesulfonyl chloride (8.4 g, 43.8 mmol). The mixture was allowed to stir at ambient temperature for 72 h then was quenched with 5percent aqueous HCl (20 mL). The layers were separated and the aqueous phase was extracted with CH2Cl2 (3.x.7 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 75percent hexanes in EtOAc) afforded the title compound (8.0 g, 29.8 mmol, 68percent yield). MS (DCI/NH3) m/z 286 (M+NH4)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
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