Application of 27871-49-4, Adding some certain compound to certain chemical reactions, such as: 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate,molecular formula is C4H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27871-49-4.
To a solution of Intermediate Gen-14-b (694 g, 6.67 mol, 1 eq.) in DCM (7 L) under stirring and nitrogen, are added 1H-imidazole (500 g, 7.34 mol, 1.1 eq.) and Intermediate Gen-9-b (1055 g, 7.00 mol, 1.05 eq.). The reaction mixture is cooled during the addition, then stirred at room temperature overnight under nitrogen. The reaction mixture is diluted in IPE (5.5 L), the organic layer is washed once with an aqueous 1 M HCl solution (2.8 L), once with a mixture of an aqueous 1 M HCl solution and brine (1/1) (1.4 L/1.4 L) and once with brine (2.8 L), dried over Na2SO4, filtered and evaporated to dryness to give Intermediate Gen-15-b. 1H NMR (300 MHz, CDCl3-d) delta ppm 4.34 (1H, q), 3.73 (3H, s), 1.40 (3H, d), 0.91 (9H, s), 0.90 (6H, d)
According to the analysis of related databases, 27871-49-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BONNATERRE, Florence Marie-Emilie; BEAUMONT, Stephane Nicolas Alain; US2015/80391; (2015); A1;,
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