Reference of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.
Step A Synthesis of Compound Int-19a TBDPSC1 (9.0 mL, 35.0 mmol) was added dropwise to a stirred hazy solution of 2- methylenepropane-l,3-diol (3 g, 34.1 mmol) and imidazole (4.70 g, 69.0 mmol) in DCM (340 mL). The reaction mixture was stirred at room temperature overnight. The following morning, the reaction mixture was concentrated under reduced pressure (~80 mL) before being filtered through a pad of celite, rinsing over with additional DCM / MeOH. The filtrate was evaporated under reduced pressure. The resulting oil was purified by silica gel column (220 g) (0452) chromatography eluting with 0-20% EtOAc / hexanes to afford compound Int-19a. NMR (500 MHz, CDCb): d 7.69 (d, J = 7.4 Hz, 4H); 7.49 – 7.37 (m, 6H); 5.16 (app. s, 1H); 5.13 (app. s, 1H); 4.27 (s, 2H); 4.19 (d, J = 6.2 Hz, 2H); 1.80 (t, J = 6.1 Hz, 1H); 1.08 (s, 9H).
According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Tao; APGAR, James, M.; WHITEHEAD, Alan; ZHANG, Yonglian; HU, Zhiyong; SHURTLEFF, Valerie, W.; MCCAULEY, John, A.; RAHEEM, Izzat, T.; (97 pag.)WO2019/209667; (2019); A1;,
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