Electric Literature of 2615-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, molecular weight is 282.33, as common compound, the synthetic route is as follows.
j00346j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (5 g, 1.70 mmol) in THF (100 mL) was charged with tosyl chloride (10.1 g, 5.30 mmol) and solution of potassium hydroxide (5.9 g, 5.30 mmol) in H20 (100 mL) at room temperature. The resulting solution was heated to 60 C for 5 h then cooled to room temperature and evaporated in vacuo. Theresidue obtained was diluted with DCM (100 mL) and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCM to obtain 8 g, 76% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.94 Hz, 4H), 7.48 (d, J= 8.38 Hz, 4H), 4.08-4.13 (m, 4H), 3.54-3.59 (m, 4H), 3.43 -3.50 (m, 16H), 2.42 (s, 6H).
Statistics shows that 2615-15-8 is playing an increasingly important role. we look forward to future research findings about 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.
Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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