Electric Literature of 530-91-6 , The common heterocyclic compound, 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stuffed solution of 1,2,3,4-tetrahydronaphthalen-2-ol (250 mg, 1.68 mmol) in DCM (5 mL) was added triethylamine (1.17 mL, 8.50 mmol) at 0 C followed by addition of mesyl chloride (0.26 mL, 3.35 mmol). The reaction mixture was then stirred at 0 C for 2 h. The reaction was monitored by ?H NMR. After completion of reaction, the mixture was quenched with ice, and extracted with DCM (2×50 mL). The combined organic layer was dried over sodium sulfate and concentrated to afford 340 mg of 1 ,2,3,4-tetrahydronaphthalen- 2-yl methanesulfonate as a brown liquid which was taken to the next step without further purification.
The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; GREEN, Michael, John; PHAM, Son, Minh; PUJALA, Brahmam; AGARWAL, Anil, Kumar; NAYAK, Ajan, Kumar; KHARE, Sweta; GUGULOTH, Rambabu; RANDIVE, Nitin, Atmaram; WO2015/58084; (2015); A1;,
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