Electric Literature of 10602-04-7, Adding some certain compound to certain chemical reactions, such as: 10602-04-7, name is (4-Ethynylphenyl)methanol,molecular formula is C9H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10602-04-7.
4-Ethynyl benzyl bromide. A solution of triphenylphosphine (3.9 g, 15 mmol) in CH2Cb (5 mL) was added dropwise to a cold mixture of 4-ethynylbenzylalcohol (1.0 g, 7.6 mmol), tetrabromomethane (4.5 g, 14 mmol), and 2,6-lutidine (4.4 mL, 38 mmol) in CH2Cb (20 mL) at 5 °C and the mixture was stirred for 16 h at RT. After concentration in vacuo, the residue was treated with ether (40 mL) and the resulting solid was removed by filtration. The filtrate was washed with 1percent HC1 solution and then water, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography to give 4- ethynylbenzyl bromide (1.4 g, 95percent) as a pale yellow oil. 1H NMR (600 MHz, CDCb) delta 7.46 (d, 2H, J=7.8), 7.34 ( d, 2H, J=7.8), 4.47 (s, 2H), 3.10 (s, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE BRIGHAM AND WOMEN’ S HOSPITAL, INC.; CUNNINGHAM, James; LEE, Kyungae; REN, Tao; CHANDRAN, Kartik; WO2013/22550; (2013); A2;,
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