Adding a certain compound to certain chemical reactions, such as: 445-26-1, 1-(2-Fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1-(2-Fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Quality Control of 1-(2-Fluorophenyl)ethanol
General procedure: In a vacuum dried 100 mL Schlenk flask, secondary or primary benzyl alcohol I (10.0 mmol),4-dimethylaminopyridine (2 mmol), and triethylamine (2.78 mL, 20.0 mmol) were dissolved inTHF (50 mL) under Ar atmosphere. Then, HClSiiPr2 or HClSiMetBu (12 mmol) was added atroom temperature and the reaction mixture was stirred overnight at room temperature or 50 oC.After the reaction was complete (monitored by TLC or GC-MS), the reaction mixture was filteredto remove the white precipitate and the solvent was removed via rotary evaporation. Water (20 mL)and MTBE (20 mL) were added, and the mixture was extracted with MTBE (20 mL×3). Thecombined organic layer was washed with saturated sodium chloride (20 mL), and dried overNa2SO4. Evaporation of organic solvent afforded a colorless liquid, which was further purified byflash silica column chromatography with petroleum ether as the eluent to give the corresponding(hydrido)silyl ether product as a colorless liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,445-26-1, 1-(2-Fluorophenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Fang, Huaquan; He, Qiaoxing; Liu, Guixia; Huang, Zheng; Synlett; vol. 28; 18; (2017); p. 2468 – 2472;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts