Electric Literature of 147034-01-3 , The common heterocyclic compound, 147034-01-3, name is (2,5-Dibromophenyl)methanol, molecular formula is C7H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of (2,5-dibromo-phenyl)-methanol (40 g, 150 mmol) and triphenylpho spine (59 g, 230 mmol) in THF (1000 mL) at 0 C is added carbon tetrabromide (75 g, 230 mmol) slowly. The reaction mixture is stirred at room temperature for 2 hr and the solvent is removed to give the crude product. Purification by flash column chromatography affords 40 g of 1,4- dibromo-2-bromomethyl -benzene.
The synthetic route of 147034-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; COGAN, Derek; GUO, Xin; MARSHALL, Daniel Richard; MEYERS, Kenneth Michael; ZHANG, Yunlong; (130 pag.)WO2016/89800; (2016); A1;,
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