Electric Literature of 112-70-9 ,Some common heterocyclic compound, 112-70-9, molecular formula is C13H28O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: 2-Chloro-1-methylpyridinium iodide (CMPI, 3.32 g, 13 mmol) and N,N-dimethylaminopyridine (DMAP, 3.18 g, 26 mmol) were added to a solution of N-boc-glycine (9) (1.75 g, 10 mmol) and dodecanol (2.47 mL, 10 mmol) in dry DCM (20 mL) at 0 C and the mixture was stirred at 0 C for 30 min. After the mixture was diluted with AcOEt, the resulting precipitates were filtered off. The filtrates were successively washed with aqueous 5% HCl, saturated aqueous NaHCO3 and brine, dried over Na2SO4, and evaporated. The resulting crude product was purified by flash CC (silica gel; AcOEt/DCM, 5:95) to provide the dodecyl ester 10a (2.78 g, 81%). Tridecyl ester 10b (86%), tetradecyl ester 10c (82%), pentadecyl ester 10d (74%) and hexadecyl ester 11e (79%) were similarly prepared from N-boc-glycine (9).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-70-9, its application will become more common.
Reference:
Article; Yamano, Yumiko; Tsuboi, Kazuhito; Hozaki, Yuki; Takahashi, Kiyohiro; Jin, Xing-Hua; Ueda, Natsuo; Wada, Akimori; Bioorganic and Medicinal Chemistry; vol. 20; 11; (2012); p. 3658 – 3665;,
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