The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 722-92-9
Step A: 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol To a stirred solution of copper(II) bromide (1.293 g, 5.79 mmol) in acetonitrile (15 mL) was added tert-butyl nitrite (0.764 mL, 5.79 mmol) in one portion at 60¡ã C. A solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1 g, 3.86 mmol) in acetonitrile (3 mL) was then added dropwise at 60¡ã C. After stirring for 15 min at 60¡ã C., the mixture was concentrated. The residue was diluted with water (20 mL) and extracted with EtOAc (10 mL, 2*4 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated. Flash chromatography purification using (24 g silica gel column, gradient elution from 0 to 30percent of ethyl acetate in hexanes) afforded 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.3 g, 4.02 mmol, 104percent yield) as a liquid.
Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.
Reference:
Patent; Duan, Jingwu; Dhar, T. G. Murali; Jiang, Bin; Lu, Zhonghui; Xiao, Hai-Yun; US2015/191483; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts