Application of 4442-79-9, Adding some certain compound to certain chemical reactions, such as: 4442-79-9, name is 2-Cyclohexylethanol,molecular formula is C8H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4442-79-9.
A flame-dried 50 mL flask was charged with 2-cyclohexylethanol (1.00 equiv., 696 mg, 5.00 mmol) in dry THF (10 mL). The mixture was cooled at 0 C and sodium hydride (60 wt% on mineral oil, 1.50 equiv., 300 mg, 7.50 mmol) was added in one portion. After stirring for 10 min, allyl bromide (1.50 equiv., 0.65 mL, 7.50 mmol) was added dropwise at the same temperature. The cooling bath was removed and the suspension was stirred at r.t. for 30 min. The reaction mixture was then heated to reflux for 16 h. After full conversion, the suspension was cooled to r.t. and quenched by the addition of a saturated aqueous solution of NH4Cl (10 mL). The biphasic mixture was then extracted with Et2O (3 x 10 mL). The combined organic layers were dried over Na2SO4, and concentrated in vacuo. The crude material was purified by column chromatography on silica gel (Pet.Ether/EtOAc 100:1); Colorless oil; 87% yield; 1H NMR (200 MHz, CDCl3) delta: 5.98-5.73 (1H, m, =CH), 5.21 (1H, d, J = 17.2 Hz, =CHH), 5.10 (1H, d, J = 10.4 Hz, =CHH), 3.90 (2H, d, J = 4.0 Hz, OCH2), 3.40 (2H, t, J = 6.6 Hz, OCH2), 1.76-1.49 (5H, m, 2 x CH2 and CH), 1.49-1.33 (3H, m, 3 x CHH), 1.22-1.05 (3H, m, 3 x CHH), 0.73-0.69 (2H, m, 2x CHH); 13C NMR (50 MHz, CDCl3) delta: 135.0, 116.4, 71.7, 68.2, 37.1, 34.4, 33.3, 26.5, 26.2; MS 169 [M+H]+.
According to the analysis of related databases, 4442-79-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Voutyritsa, Errika; Nikitas, Nikolaos F.; Apostolopoulou, Mary K.; Gerogiannopoulou, Anna Dimitra D.; Kokotos, Christoforos G.; Synthesis; vol. 50; 17; (2018); p. 3395 – 3401;,
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