Application of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.
10129] l3enzyl glycolate (30 g, 0.25 mol) and Hoc anhydride (39.1 g, 0.19 mol) were dissolved in 30 ml of dichloromethane. 5 ml of DMAP (4.62 g, 0.038 mol) in dichloromethane solution was added dropwise into the resultant reaction liquid at 80 C. Afier that, the reaction liquid was reacted at 15 C. for 0.5 h. Afier completion of the reaction, the reaction liquid was poured into ice water, extracted with ethyl acetate, the combined resultant organic phase was washed with water and saturated salt water successively. The organic phase was concentrated and recrystallized with petroleum ether/ethyl acetate in a ratio of 10:1 to give a white solid (32.5 g, 66%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.
Reference:
Patent; JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.; Zhou, Wei; Jing, Yunrong; Wang, Yongfeng; Wang, Guocheng; (81 pag.)US2016/340365; (2016); A1;,
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