Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4464-18-0, name is Benzene-1,3,5-triyltrimethanol. A new synthetic method of this compound is introduced below., name: Benzene-1,3,5-triyltrimethanol
1 ,3,5-Tris(hydroxymethyl)benzene 15 (927 mg, 5.12 mmol) was suspended in CH2CI2 (25 mL) and solid PCC (5.94g, 27.6 mmol) was added. After 30 minutes of stirring, the reaction was diluted with acetone (10 mL) and was allowed to stir for 3 hr at RT. TLC (10% MeOH, 90% CH2CI2 Rf=0.50) was used to determine if the reaction was complete. After the reaction was complete, the precipitated chromium salts were filtered off and washed with CH2CI2. The aqueous layer was extracted 3 times in CH2CI2 and saturated Na2CO3. The organic layers were combined and dried over anhydrous Na2SO4, filtered, and concentrated. Flash column chromatography (100% CH2CI2 Rf=0.4) gave 16 (272 mg, 1.68 mmol, 33%). 1H NMR (CDCI3): delta 10.21 (s, 3H), 8.63 (s, 3H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4464-18-0, Benzene-1,3,5-triyltrimethanol.
Reference:
Patent; UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.; PHANSTIEL, Otto; ARCHER, Jennifer, J.; WO2010/148390; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts