As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C4H11NO2
To a single-neck flask was added 2-(2-aminoethoxyl)ethanol (10.500 g). Tetrahydrofuran (25 mL) was added to dissolve 2-(2-aminoethoxyl)ethanol. Anhydrous sodium carbonate (5.300 g) was dissolved in distilled water (30 mL). The solution was added into the single-neck flask and cooled in an ice bath. Di-t-butyl dicarbonate (28.340 g) was dissolved in tetrahydrofuran (70 mL). The resultant solution was slowly dropwise added in the reaction system (for about 1 hr). After the addition, the mixture was stirred for 1.5 hr. After the reaction was completed, the reaction solution was filtered by suction. The filter cake was washed with tetrahydrofuran twice and then discarded. The filtrate was concentrated, then dissolved in ethyl acetate (150 mL) and distilled water (100 mL). The solution was mixed and then stood to separate. The aqueous phase was washed again with ethyl acetate (100 mL*2) twice. All the organic phases were combined, dried over MgSO4, filtered and concentrated to give the target compound.
With the rapid development of chemical substances, we look forward to future research findings about 929-06-6.
Reference:
Patent; Zhang, Hesheng; Huo, Aihong; Li, Zhenzhong; US2015/166595; (2015); A1;,
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