Related Products of 111-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.
Sodium hydroxide (2.56 g, 63.99 mmol) was completely dissolved in distilled water and a solution of THF and Allyloxy ethanol (5.83 ml, 54.55 mmol) was added at 0 C. After stirring for 30 minutes, a solution of 4-Toluenesulfonyl chloride (10 g, 52.45 mmol) in THF at 0 C was slowly added. After that, the temperature was raised to room temperature and then stirred for 1 hour. The reaction was terminated by adding cold distilled water and extracted with hexane. The extracted organic layer was washed with water and aqueous NaCl solution, and dried over MgSO4. The reaction product (1EO-OTs) was dried in a vacuum oven (Yield = 33%).
Statistics shows that 111-45-5 is playing an increasingly important role. we look forward to future research findings about 2-(Allyloxy)ethanol.
Reference:
Patent; Korea Research Institute of Chemical Technology; Han Mi-jeong; Kang Yeong-gu; Seok Jeong-don; Kwak Hyeon-ju; (29 pag.)KR101826496; (2018); B1;,
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Alcohols – Chemistry LibreTexts