Electric Literature of 92093-23-7 ,Some common heterocyclic compound, 92093-23-7, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A diol 6c or 6d or 6e (2 equiv) and PPTS (0.1 equiv) was added to a toluene (25.0 mL/1 mmol of substrate) solution of a substituted-4,4-dimethoxycyclohexa-2,5-dienone 5a or 5b (1 equiv) at room temperature. After stirring at 40 C for 18 h, the reaction mixture was quenched by the addition of saturated aqueous NaHCO3 and the product was extracted with ethyl acetate three times. The combined organic extracts were washed with brine, dried over anhydrous magnesium sulphate, filtered, and concentrated under reduced pressure. The residue was purified by preparative TLC to give the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92093-23-7, its application will become more common.
Reference:
Article; Fuse, Shinichiro; Inaba, Kennichi; Takagi, Motoki; Tanaka, Masahiro; Hirokawa, Takatsugu; Johmoto, Kohei; Uekusa, Hidehiro; Shin-ya, Kazuo; Takahashi, Takashi; Doi, Takayuki; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 180 – 184;,
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