Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H18O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C11H18O
COMPARATIVE EXAMPLE 1 Synthesis of 2-methyl-2-adamantyl alpha-trifluoromethylacrylate [MAFAC] from 2-methyl-2-adamantanol and alpha-trifluoromethylacryloyl Chloride A 500 ml flask was flushed with nitrogen to displace the air with nitrogen, and was charged with 83.1 g (0.50 mol) of 2-methyl-2-adamantanol, 101.2 g (1.0 mol) of triethylamine and 200 g of tetrahydrofuran. Then 118.9 g (0.75 mol) of alpha-trifluoromethylacryloyl chloride was dropwise added to the content in the flask over a period of about 1 hour, while the content was maintained at a reaction temperature of about 0 C. Then the content was stirred for 10 hours at room temperature. After completion of the reaction, the reaction mixture was washed with water and then with an aqueous saturated sodium chloride solution. The thus-obtained organic phase was subjected to column chromatography, and further, analyzed by NMR and mass spectrometry. Thus, 101.2 g (yield: 70.3%) of the object 2-methyl-2-adamantyl alpha-trifluoromethylacrylate was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; TOSOH CORPORATION; US2003/139613; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts