Application of 34231-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Fmoc-OSu (38.6 g, 1 15 mmol) was added to a solution of [3-(amino- methyl)phenyl]methanol (S14, 16.5 g, 121 mmol) in THF (150 ml_), water (75 ml_) and sodium bicarbonate (20.3 g, 241 mmol) at room temperature (rt) and the reaction stirred overnight (o/n). At that point, a small sample was diluted with MeOH, acidified with a drop of HOAc, and analyzed by LC-MS, which showed the desired product with no Fmoc-OSu reagent. The reaction was acidified with 1 M HCI, diluted with ethyl acetate (EtOAc), and stirred for 2 h. The white solid was filtered off, washed well with water, then EtOAc, and air dried for 3 h until a constant weight was attained. The product thus obtained, Fmoc-S14 (15.3 g), was found by LC-MS to be free of identifiable organic impurities. The aqueous layer was extracted with EtOAc (2x). The combined organic layers were washed with H2O (2x) and brine, then dried over anhydrous MgSO4. The dessicant was removed by filtration and the filtrate concentrated under reduced pressure to give additional amounts of the desired product as a white solid (34.1 g). The combined solids were triturated with ethyl acetate at reflux for a few minutes, then o/n at rt to give Fmoc-S14 in 88% yield (38.1 g).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 34231-22-6, 3-(Aminomethyl)benzyl Alcohol.
Reference:
Patent; CYCLENIUM PHARMA INC.; WAHHAB, Amal; DUBE, Daniel; MACDONALD, Dwight; PETERSON, Mark L.; RICHARD, Luc; THOMAS, Helmut; (313 pag.)WO2018/232506; (2018); A1;,
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